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- FOXO3-engineered human mesenchymal progenitor cells . . . - PubMed
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction Protein Cell 2021 Feb;12(2):145-151 doi: 10 1007 s13238-020-00779-7
- Phosphorylation and acetylation modifications of FOXO3a: Independently . . .
Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being a tumor suppressor and longevity factor The precise regulation of FOXO3a transactivation of target genes is achieved via post-translational modifications (PTMs) and specific protein-protein interactions
- FOXO3-Engineered Human ESC-Derived Vascular Cells Promote . . . - Cell Press
FOXO3 + + and FOXO3 2SA 2SA hMSCs derived from hESCs both exhibited features typical of mesenchymal progenitor cells, including expression of the hMSC markers CD90, CD73, and CD105 and epigenetic silencing of the OCT4 promoter (Figures 4A, S4A, and S4B)
- FoxO3 controls cardiomyocyte proliferation and heart . . . - Nature
We reveal that FoxO3 directly promotes the expression of secreted frizzled-related protein 2 (Sfrp2) and suppresses the activation of canonical Wnt β-catenin signaling during heart regeneration
- FOXO3-engineered human mesenchymal progenitor cells efficiently promote . . .
Among cell-based therapies in clinical development, mesenchymal progenitor cells (MPCs) are attractive candidates due to their multi-lineage potential and immunomodulatory properties (Bagno et al , 2018)
- Akt-FOXO3a Signaling Affects Human Endothelial Progenitor Cell . . .
The role of FOXO3a during endothelial progenitor cell differentiation, using enforced expression of activated FOXO3a Transfection efficiency for adenovirus into human EPCs was estimated by counting GFP-expressing cells
- FoxO3a Functions as a Key Integrator of Cellular Signals That Control . . .
Here, we identified FoxO3a, a common phosphorylation target for Akt and ERK, as a key transcription factor that integrates the signals from these pathways
- Overexpression or silencing of FOXO3a affects proliferation of . . .
Overexpression of FOXO3a suppressed EPC proliferation and modulated expression of the cell cycle regulatory proteins including upregulation of the cell cycle inhibitor p27(kip1) and downregulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 and proliferating cell nuclear antigen (PCNA)
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