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- Huntingtin - Wikipedia
Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage
- HTT huntingtin [Homo sapiens (human)] - Gene - NCBI
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
- Targeting Huntingtin Expression in Patients with Huntington’s Disease
IONIS-HTT Rx (hereafter, HTT Rx) is an antisense oligonucleotide designed to inhibit HTT messenger RNA and thereby reduce concentrations of mutant huntingtin We conducted a randomized,
- New Understanding of How Genetic Mutation Causes Huntington’s Disease
For 30 years, researchers have known that Huntington’s disease is caused by an inherited mutation in the Huntingtin (HTT) gene in which a three-letter DNA sequence, C-A-G, is repeated at least 40 times
- Huntington Disease | Learn Science at Scitable - Nature
HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease George Huntington (Figure 1) was the first person to provide a comprehensive description of adult-onset HD
- The Biology of Huntingtin - PubMed
Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD)
- Htt Gene: Functions, Disorders, and Therapeutic Strategies - Genetics
The Htt gene is responsible for encoding the huntingtin protein (Htt) Htt protein plays a vital role in various cellular processes, including transcriptional regulation and gene expression
- HTT Gene | Huntingtons Victoria
The HTT gene, located on Chromosome 4, provides instructions for producing a vital protein called huntingtin While the precise role of this protein remains unclear, it holds significance in nerve cells (neurons) within the brain and is crucial for normal development before birth
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