Aphidicolin | Cell Signaling Technology Aphidicolin is a tetracyclic diterpenoid first produced by the fungus Cephalosporium aphidicola This antibiotic is a potent inhibitor of cellular deoxyribonucleic acid (DNA) synthesis by targeting α, ε, and δ DNA polymerases in eukaryotic cells lines with little to no effect on β or γ DNA polymerases (1,2)